Protective Effects of Withania somnifera Root on Inflammatory Markers and Insulin Resistance in Fructose-Fed Rats

نویسندگان

  • Alireza Nakhaei Department of Pharmacology, Zahedan University of Medical Sciences, Zahedan, Iran
  • Davood Nourabadi Department of Physiology, Iran University of Medical Sciences, Tehran, Iran
  • Hassan Ahmadvand Department of Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorram Abad, Iran
  • Mohammad Reza Shahraki Department of Physiology, Zahedan University of Medical Sciences, Zahedan, Iran
  • Zahra Samadi Noshahr Department of Pharmacology, Zahedan University of Medical Sciences, Zahedan, Iran
چکیده مقاله:

Background: We investigated the effects of Withania somnifera root (WS) on insulin resistance, tumor necrosis factor &alpha; (TNF-&alpha;), and interleukin-6 (IL-6) in fructose-fed rats. Methods: Forty-eight Wistar-Albino male rats were randomly divided into four groups (n=12); Group I as control, Group II as sham-treated with WS by 62.5mg/g per diet, Group III fructose-fed rats received 10%W/V fructose, and Group IV fructose- and WS-fed rats. After eight weeks blood samples were collected to measure glucose, insulin, IL-6, and TNF-&alpha; levels in sera. Results: Blood glucose, insulin, homeostasis model assessment for insulin resistance (HOMA-R), IL-6, and TNF-&alpha; levels were all significantly greater in the fructose-fed rats than in the controls. Treatment with WS significantly (P < 0.05) inhibited the fructose-induced increases in glucose, insulin, HOMA-R, IL-6, and TNF-&alpha;. Conclusion: Our data suggest that WS normalizes hyperglycemia in fructose-fed rats by reducing inflammatory markers and improving insulin sensitivity.

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protective effects of withania somnifera root on inflammatory markers and insulin resistance in fructose-fed rats

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عنوان ژورنال

دوره 3  شماره 2

صفحات  62- 67

تاریخ انتشار 2015-05

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